Literature summary for 3.4.24.56 extracted from

Farris, W.; Mansourian, S.; Leissring, M.A.; Eckman, E.A.; Bertram, L.; Eckman, C.B.; Tanzi, R.E.; Selkoe, D.J.
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein (2004), Am. J. Pathol., 164, 1425-1434.

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Protein Variants

Protein Variants	Comment	Organism
H18R/A890V	plus silent mutation at codon 934, naturally occuring missense mutations occuring in a rat model of type 2 diabetes mellitus, resulting in decreased catalytic efficiency and 15-30% deficit in degradation of both insulin and insulin Abeta. Endogenously secreted insulin Abeta40 and Abeta42 are significantly elevated in primnary neuronal cultures from mutant animals	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P35559	-	-

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Release 2023.1 (January 2023)