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Literature summary for 3.4.24.56 extracted from
- Substrate studies for insulin-specific protease (1973), Eur. J. Biochem., 37, 489-496.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000158 | - |
desalanine-insulin | - |
Rattus norvegicus | |
| 0.000022 | - |
Insulin | - |
Rattus norvegicus | |
| 0.0000244 | - |
monoarginine-insulin | diarginine-insulin | Rattus norvegicus | |
| 0.000044 | - |
destridecapeptide-proinsulin | - |
Rattus norvegicus | |
| 0.000055 | - |
desnonapeptide-proinsulin | - |
Rattus norvegicus | |
| 0.000176 | - |
desdipeptide-proinsulin | - |
Rattus norvegicus | |
| 0.0002342 | - |
Proinsulin | cleaved | Rattus norvegicus | |
| 0.0008572 | - |
Proinsulin | - |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| desalanine-insulin + H2O | - |
Rattus norvegicus | ? | - |
? |  |
| desdipeptide-proinsulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| desnonapeptide-proinsulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| destridecapeptide-proinsulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| Insulin + H2O | - |
Rattus norvegicus | Hydrolyzed insulin | - |
? | |
| monoarginine-insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | requirement for optimal substrate activity is the deblocking of the amino end of the A-chain | Rattus norvegicus | ? | - |
? | |
| Porcine proinsulin intermediates + H2O | cleaved proinsulin, desdipeptide-proinsulin, desnonapeptide-proinsulin, destridecapeptide-proinsulin, desalanine-insulin, monoarginine-insulin and diarginine-proinsulin are degraded at 19.8%, 25.6%, 63.5%, 73.7%, 101.5%, 98% and 98% of the activity of insulin, respectively | Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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