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Literature summary for 3.4.24.47 extracted from

  • Bjarnason, J.B.; Fox, J.W.
    Horrilysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 681-682.
No PubMed abstract available

Application

Application Comment Organism
medicine horrilysin possesses hemorrhagic and lethal activities Crotalus horridus horridus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
SDS-PAGE Crotalus horridus horridus

Organism

Organism UniProt Comment Textmining
Crotalus horridus horridus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by two step column chromatography Crotalus horridus horridus

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Crotalus horridus horridus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O
-
Crotalus horridus horridus ?
-
?
cow hide powder + H2O hydrolysis only at 20% of the rate at which hide powder azure is hydrolyzed Crotalus horridus horridus ?
-
?
Denatured casein + H2O
-
Crotalus horridus horridus ?
-
?
Fibrin + H2O degradation of the alpha chain Crotalus horridus horridus ?
-
?
Fibrinogen + H2O rapid digestion of the Aalpha chain followed by a slower degradation of the Bbeta chain Crotalus horridus horridus ?
-
?
glomerular basement membrane + H2O catalysis of the complete solubilization Crotalus horridus horridus ?
-
?
Hemoglobin + H2O
-
Crotalus horridus horridus ?
-
?
hide powder azure + H2O
-
Crotalus horridus horridus ?
-
?
insulin + H2O cleavage of the Val-Glu-Ala15-Leu16-Tyr-Leu bond of the B chain and Val-Cys-Ser12-Leu13-Tyr-Gly bond of the A chain Crotalus horridus horridus ?
-
?
Melittin + H2O cleavage at the Ile2-Gly3, Pro14-Ala15 and Ser18-Trp19 bonds Crotalus horridus horridus ?
-
?
additional information no cleavage of various unblocked dipeptides and the doubly blocked dipeptides Z-Ser-Leu-NH2, Z-Ala-Leu-NH2 and Z-Ile-Gly-NH2 Crotalus horridus horridus ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Crotalus horridus horridus

Synonyms

Synonyms Comment Organism
Hemorrhagic proteinase IV
-
Crotalus horridus horridus
HP-IV
-
Crotalus horridus horridus