Application | Comment | Organism |
---|---|---|
medicine | horrilysin possesses hemorrhagic and lethal activities | Crotalus horridus horridus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57000 | - |
SDS-PAGE | Crotalus horridus horridus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus horridus horridus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by two step column chromatography | Crotalus horridus horridus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus horridus horridus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | - |
Crotalus horridus horridus | ? | - |
? | |
cow hide powder + H2O | hydrolysis only at 20% of the rate at which hide powder azure is hydrolyzed | Crotalus horridus horridus | ? | - |
? | |
Denatured casein + H2O | - |
Crotalus horridus horridus | ? | - |
? | |
Fibrin + H2O | degradation of the alpha chain | Crotalus horridus horridus | ? | - |
? | |
Fibrinogen + H2O | rapid digestion of the Aalpha chain followed by a slower degradation of the Bbeta chain | Crotalus horridus horridus | ? | - |
? | |
glomerular basement membrane + H2O | catalysis of the complete solubilization | Crotalus horridus horridus | ? | - |
? | |
Hemoglobin + H2O | - |
Crotalus horridus horridus | ? | - |
? | |
hide powder azure + H2O | - |
Crotalus horridus horridus | ? | - |
? | |
insulin + H2O | cleavage of the Val-Glu-Ala15-Leu16-Tyr-Leu bond of the B chain and Val-Cys-Ser12-Leu13-Tyr-Gly bond of the A chain | Crotalus horridus horridus | ? | - |
? | |
Melittin + H2O | cleavage at the Ile2-Gly3, Pro14-Ala15 and Ser18-Trp19 bonds | Crotalus horridus horridus | ? | - |
? | |
additional information | no cleavage of various unblocked dipeptides and the doubly blocked dipeptides Z-Ser-Leu-NH2, Z-Ala-Leu-NH2 and Z-Ile-Gly-NH2 | Crotalus horridus horridus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Crotalus horridus horridus |
Synonyms | Comment | Organism |
---|---|---|
Hemorrhagic proteinase IV | - |
Crotalus horridus horridus |
HP-IV | - |
Crotalus horridus horridus |