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Literature summary for 3.4.24.42 extracted from

  • Shannon, J.D.; Baramova, E.N.; Bjarnason, J.B.; Fox, J.W.
    Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin (1989), J. Biol. Chem., 264, 11575-11583.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Collagenase inhibitor SC 44463
-
Crotalus atrox
cysteine
-
Crotalus atrox
EDTA
-
Crotalus atrox
additional information iodoacetate; no inhibition by aprotinin, PMSF Crotalus atrox
phosphoramidon weak, isozyme Ht-d Crotalus atrox
thiorphan
-
Crotalus atrox

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloproteinase Crotalus atrox

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
amino acid composition Crotalus atrox
additional information
-
they differ by a single amino acid substitution at position 181, Ala (Cc) or Asp (Cd) Crotalus atrox
23230
-
Crotalus atrox, isozyme Ht-d Crotalus atrox

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Basement membranes surrounding capillaries + H2O Crotalus atrox involved in disruption of capillary membranes causing hemorrhage in surrounding tissue ?
-
?

Organism

Organism UniProt Comment Textmining
Crotalus atrox
-
Western diamondback rattlesnake
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O
-
Crotalus atrox ?
-
?
Basement membranes surrounding capillaries + H2O involved in disruption of capillary membranes causing hemorrhage in surrounding tissue Crotalus atrox ?
-
?
Collagen type IV + H2O basement membrane component, alpha1 (MW 185000) and alpha2 (MW 170000) chain Crotalus atrox Hydrolyzed collagen type IV MW 170000, MW 164000, MW 125000, MW 110000, MW 940000 and MW 64000 fragments ?
Gelatin of collagen type I + H2O i.e. denatured collagen Crotalus atrox Hydrolyzed gelatin of collagen type I MW 60000 and MW 50000 fragments ?
Gelatin of collagen type III + H2O i.e. denatured collagen Crotalus atrox ?
-
?
Gelatin of collagen type V + H2O i.e. denatured collagen, hydrolysis at 38ΓΈC and above, not below Crotalus atrox Hydrolyzed gelatin of collagen type V MW 130000, MW 118000, MW 93000 and MW 85000 fragments ?
additional information no hydrolysis of interstitial collagen, native type I collagen Crotalus atrox ?
-
?