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Literature summary for 3.4.24.41 extracted from
- Atrolysins: metalloproteinases from Crotalus atrox venom (1995), Methods Enzymol., 248, 368-387.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Crotalus atrox |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Crotalus atrox |  |
| EDTA | - |
Crotalus atrox | |
| Hemorrhagic toxin inhibitor from Crotalus atrox | - |
Crotalus atrox |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc metalloproteinase, 1 mol zinc/mol enzyme | Crotalus atrox | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Basement membranes surrounding capillaries + H2O | Crotalus atrox | involved in disruption of capillary membranes, together with atrolysins C and E member of the class P-I hemorrhagic toxins, most abundant hemorrhagic toxin in the venom | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crotalus atrox | - |
Western diamondback rattlesnake | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| additional information | no glycoprotein | Crotalus atrox |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from lyophilized crude venom | Crotalus atrox |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Crotalus atrox | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Basement membrane preparation + H2O | - |
Crotalus atrox | Soluble peptides | - |
? | |
| Basement membranes surrounding capillaries + H2O | involved in disruption of capillary membranes, together with atrolysins C and E member of the class P-I hemorrhagic toxins, most abundant hemorrhagic toxin in the venom | Crotalus atrox | ? | - |
? | |
| Fibrinogen + H2O | - |
Crotalus atrox | Hydrolyzed fibrinogen | - |
? | |
| Laminin + H2O | - |
Crotalus atrox | ? | - |
? | |
| additional information | no hydrolysis of fibrin | Crotalus atrox | ? | - |
? | |
| additional information | possesses hemorrhagic, proteolytic and myonecrotic activity | Crotalus atrox | ? | - |
? | |
| Nidogen + H2O | basement membrane component | Crotalus atrox | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 8.2, estimated from amino acid sequence | Crotalus atrox |
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Release 2023.1 (January 2023)
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