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Literature summary for 3.4.24.40 extracted from
- A novel serralysin metalloprotease from Deinococcus radiodurans (2008), Biochim. Biophys. Acta, 1784, 1256-1264.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | complete inhibition | Deinococcus radiodurans |  |
| Ca2+ | inhibitory above 0.1 mM | Deinococcus radiodurans | |
| Co2+ | inhibitory above 5 mM | Deinococcus radiodurans | |
| EDTA | complete inhibition | Deinococcus radiodurans | |
| EGTA | complete inhibition | Deinococcus radiodurans | |
| additional information | not inhibitory: PMSF, E-64 and pepstatin | Deinococcus radiodurans | |
| Zn2+ | inhibitory above 0.025 mM | Deinococcus radiodurans | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | and intracellular | Deinococcus radiodurans | - |
- |
| intracellular | and extracellular | Deinococcus radiodurans | 5622 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | in presence of Ca2+, Zn2+ or Co2+ may recativate EDTA-inactivated protease. Ca2+ concentrations required are between 0.01 mM and 0.1 mM, inhibitory above 0.1 mM | Deinococcus radiodurans | |
| Co2+ | in the presence of Ca2+, restoration of EDTA-inactivied protease. No reactivation in absence of Ca2+ | Deinococcus radiodurans | |
| Zn2+ | in the presence of Ca2+, restoration of EDTA-inactivied protease. No reactivation in absence of Ca2+. Inhibitory above 0.025 mM | Deinococcus radiodurans | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
x * 85000, SDS-PAGE | Deinococcus radiodurans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Deinococcus radiodurans | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gelatin + H2O | - |
Deinococcus radiodurans | ? | - |
? | |
| additional information | no substrate: casein, bovine serum albumin, lysozyme, lactalbumin, lactoglobulin and thyroglobulin | Deinococcus radiodurans | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 85000, SDS-PAGE | Deinococcus radiodurans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DR2310 protease | - |
Deinococcus radiodurans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Deinococcus radiodurans |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 50 | - |
Deinococcus radiodurans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Deinococcus radiodurans |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 9.5 | - |
Deinococcus radiodurans |
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Release 2023.1 (January 2023)
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