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Literature summary for 3.4.24.36 extracted from

  • Arango Duque, G.; Jardim, A.; Gagnon, E.; Fukuda, M.; Descoteaux, A.
    The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole (2019), PLoS Pathog., 15, e1007982 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the endoplasmic reticulum and the Golgi hinderes the exit of GP63 metalloprotease from the parasitophorous vacuole and dampens the cleavage of host proteins by GP63 Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole. The enzyme is released from the parasite surface following phagocytosis and is redistributed to the endoplasmic reticulum of macrophages Leishmania major
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vacuole the host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole Leishmania major 5773
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Organism

Organism UniProt Comment Textmining
Leishmania major P08148
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-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
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Leishmania major
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Synonyms

Synonyms Comment Organism
GP63 metalloprotease
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Leishmania major