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Literature summary for 3.4.24.36 extracted from

  • Murase, L.S.; de Souza, J.V.P.; de Lima Neto, Q.A.; de Mello, T.F.P.; Cardoso, B.M.; Lera-Nonose, D.S.S.L.; Teixeira, J.J.V.; Lonardoni, M.V.C.; Demarchi, I.G.
    The role of metalloproteases in Leishmania species infection in the New World a systematic review (2018), Parasitology, 145, 1499-1509 .
    View publication on PubMed
Search for more literature for 3.4.24.36

Application

Application Comment Organism
medicine the monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples can be used on the laboratory routine to predict the prognostic and treatment efficacy of American tegumentary leishmaniasis Leishmania braziliensis
medicine the monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples can be used on the laboratory routine to predict the prognostic and treatment efficacy of American tegumentary leishmaniasis Leishmania panamensis
medicine the monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples can be used on the laboratory routine to predict the prognostic and treatment efficacy of American tegumentary leishmaniasis Leishmania mexicana
medicine the monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples can be used on the laboratory routine to predict the prognostic and treatment efficacy of American tegumentary leishmaniasis Leishmania guyanensis
medicine the monitoring of host MMPs levels and GP63 in Leishmania isolated from host samples can be used on the laboratory routine to predict the prognostic and treatment efficacy of American tegumentary leishmaniasis Leishmania mexicana venezuelensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibronectin + H2O Leishmania braziliensis
-
 ?
-
 ?
Fibronectin + H2O Leishmania panamensis
-
 ?
-
 ?
Fibronectin + H2O Leishmania mexicana
-
 ?
-
 ?
Fibronectin + H2O Leishmania guyanensis
-
 ?
-
 ?
Fibronectin + H2O Leishmania mexicana venezuelensis
-
 ?
-
 ?
kappa-B nuclear factor + H2O Leishmania braziliensis
-
 ?
-
 ?
kappa-B nuclear factor + H2O Leishmania panamensis
-
 ?
-
 ?
kappa-B nuclear factor + H2O Leishmania mexicana
-
 ?
-
 ?
kappa-B nuclear factor + H2O Leishmania guyanensis
-
 ?
-
 ?
kappa-B nuclear factor + H2O Leishmania mexicana venezuelensis
-
 ?
-
 ?
tyrosine phosphatase + H2O Leishmania braziliensis
-
 ?
-
 ?
tyrosine phosphatase + H2O Leishmania panamensis
-
 ?
-
 ?
tyrosine phosphatase + H2O Leishmania mexicana
-
 ?
-
 ?
tyrosine phosphatase + H2O Leishmania guyanensis
-
 ?
-
 ?
tyrosine phosphatase + H2O Leishmania mexicana venezuelensis
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania braziliensis
-
-
-
Leishmania guyanensis Q00689
-
-
Leishmania mexicana P43150
-
-
Leishmania mexicana venezuelensis
-
-
-
Leishmania panamensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
 Leishmania braziliensis
-
promastigote
-
 Leishmania panamensis
-
promastigote
-
 Leishmania mexicana
-
promastigote
-
 Leishmania guyanensis
-
promastigote
-
 Leishmania mexicana venezuelensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Leishmania braziliensis ?
-
 ?
Fibronectin + H2O
-
 Leishmania panamensis ?
-
 ?
Fibronectin + H2O
-
 Leishmania mexicana ?
-
 ?
Fibronectin + H2O
-
 Leishmania guyanensis ?
-
 ?
Fibronectin + H2O
-
 Leishmania mexicana venezuelensis ?
-
 ?
kappa-B nuclear factor + H2O
-
 Leishmania braziliensis ?
-
 ?
kappa-B nuclear factor + H2O
-
 Leishmania panamensis ?
-
 ?
kappa-B nuclear factor + H2O
-
 Leishmania mexicana ?
-
 ?
kappa-B nuclear factor + H2O
-
 Leishmania guyanensis ?
-
 ?
kappa-B nuclear factor + H2O
-
 Leishmania mexicana venezuelensis ?
-
 ?
tyrosine phosphatase + H2O
-
 Leishmania braziliensis ?
-
 ?
tyrosine phosphatase + H2O
-
 Leishmania panamensis ?
-
 ?
tyrosine phosphatase + H2O
-
 Leishmania mexicana ?
-
 ?
tyrosine phosphatase + H2O
-
 Leishmania guyanensis ?
-
 ?
tyrosine phosphatase + H2O
-
 Leishmania mexicana venezuelensis ?
-
 ?

Synonyms

Synonyms Comment Organism
glycoprotein 63
-
 Leishmania braziliensis
glycoprotein 63
-
 Leishmania panamensis
glycoprotein 63
-
 Leishmania mexicana
glycoprotein 63
-
 Leishmania guyanensis
glycoprotein 63
-
 Leishmania mexicana venezuelensis
gp63
-
 Leishmania braziliensis
gp63
-
 Leishmania panamensis
gp63
-
 Leishmania mexicana
gp63
-
 Leishmania guyanensis
gp63
-
 Leishmania mexicana venezuelensis

General Information

General Information Comment Organism
physiological function the enzyme is involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the host's immune functions, allowing the survival of the parasite and its dissemination Leishmania mexicana
physiological function the enzyme is involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the host's immune functions, allowing the survival of the parasite and its dissemination Leishmania mexicana venezuelensis
physiological function the enzyme is involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the immune functions of the host, allowing the survival of the parasite and its dissemination Leishmania braziliensis
physiological function the enzyme is involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the immune functions of the host, allowing the survival of the parasite and its dissemination Leishmania panamensis
physiological function the enzyme is involved in the degradation and cleavage of many biological molecules as kappa-B nuclear factor, fibronectin, tyrosine phosphatases. GP63 is capable of inhibiting the activity of the complement system and reduces the immune functions of the host, allowing the survival of the parasite and its dissemination Leishmania guyanensis