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Literature summary for 3.4.24.36 extracted from

  • Contreras, I.; Gomez, M.; Nguyen, O.; Shio, M.; McMaster, R.; Olivier, M.
    Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63 (2010), PLoS Pathog., 6, e1001148.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.36

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface GP63 is able to act on its substrate proteins within the nucleus of its host cell Leishmania donovani 9986
-
nucleus GP63 is able to act on its substrate proteins within the nucleus of its host cell Leishmania donovani 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
transcription factor AP-1 + H2O Leishmania donovani inactivation and degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania donovani
-
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
transcription factor AP-1 + H2O inactivation and degradation Leishmania donovani ?
-
 ?

Synonyms

Synonyms Comment Organism
gp63
-
 Leishmania donovani
surface protein GP63
-
 Leishmania donovani

General Information

General Information Comment Organism
physiological function Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63 at the cell surface, overview. GP63 but not LPG is highly involved in the mechanism responsible for the inactivation of AP-1 transcription factor. GP63 action requires macrophage lipid raft and is not dependent on parasite phagocytosis Leishmania donovani