Localization | Comment | Organism | GeneOntology No. | Textmining |
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Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania major | gp63 is the principal catalyst of proteolysis during infection. It plays a central role in a number of host cell molecular events that likely contribute to the infectivity of Leishmania | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | gp63 is the principal catalyst of proteolysis during infection. It plays a central role in a number of host cell molecular events that likely contribute to the infectivity of Leishmania | Leishmania major | ? | - |
? | |
p130Cas + H2O | phosphorylated adaptor protein of fibroblasts | Leishmania major | ? | - |
? | |
protein-tyrosine phosphatase-PEST + H2O | fibroblast protein cleaved upon infection by Leishmania major. cleavage augments its catalytic activity. Cleavage occurs likely near its C-terminal nuclear localization signal. Removal of the nuclear localization signal could allow the phosphatase to access additional substrates and also enhance its catalytic activity | Leishmania major | ? | - |
? |