Any feedback?
Literature summary for 3.4.24.36 extracted from
- The role of liposome charge on immune response generated in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) (2009), Exp. Parasitol., 121, 362-369.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | immunization of female BALB/c mice with negatively, positively charged or neutral liposomes encapsulated with rgp63, rgp63 in soluble form. The group of mice immunized with recombinant gp63 encapsulated in neutral liposomes shows a significantly smaller footpad swelling upon challenge with Leishmania major compared with positively or negatively charged liposomes. The mice immunized with neutral liposomes show the lowest splenic parasite burden, the highest IgG2a/IgG1 ratio and IFN-gamma production and the lowest IL-4 level compared to the other groups. The results indicate that a Th1 type of immune response is induced in mice immunized with neutral liposomes more efficiently than positively charged liposomes and conversely negatively charged liposomes induce a Th2 type of immune response | Leishmania major |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Leishmania major |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania major | - |
- |
- |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
