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Literature summary for 3.4.24.35 extracted from

  • Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
    Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 (2019), Nat. Prod. Res., 33, 1765-1768 .
    View publication on PubMed
Search for more literature for 3.4.24.35

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP9, quantitative RT-PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
isovitexin interacts with enzyme residues Glu241, Ala242, Pro255, Pro254, Thr251, Leu222, Tyr248, Arg241, Met247, His226, and Glu227, binding structure analysis, and modeling, overview Homo sapiens
additional information Ficus deltoidea leaf extract inhibits matrix metalloproteinase-2, 8 and 9, molecular docking, molecular dynamics, molecular dynamic simulation analysis, overview. Computational docking analysis reveals that vitexin and isovitexin binds to the active site of the three tested MMPs Homo sapiens
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid NNGH Homo sapiens
vitexin interacts with enzyme residues Gly186, Pro246, His236, Met247, Tyr248, Val223, and Leu188, binding structure analysis, and modeling, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14780
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-
EAhy 926 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
 Homo sapiens
MMP-9
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens