Literature summary for 3.4.24.35 extracted from

Baez, I.B.; Sampieri, C.L.; Solano, F.C.; Martinez Cazares, M.T.; Montero, H.; Cuevas, R.Z.
Activity of matrix metalloproteinase 2 and 9 isoforms in sputum samples from individuals infected with M. tuberculosis (2019), Microb. Pathog., 135, 103607 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene MMP9, quantitative RT-PCR enzyme expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Homo sapiens	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	a zinc-dependent metalloprotease	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Gelatin + H2O	Homo sapiens	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14780	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
sputum	Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview. Variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gelatin + H2O	-	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	four isoforms of MMP-9 have been reported: the first is a latent form, a zymogen of 92 kDa. The second is obtained by cutting the prodomain of the latent form, resulting in a product of 82 kDa, which produces the active form of the enzyme. The third isoform is a heterodimer that originates from the binding of MMP-9 with the inhibitor TIMP-1, generating a product of 220 kDa. Finally, the fourth isoform corresponds to a 125 kDa heterodimer, made up of MMP-9 associated with lipocalin. Analysis of MMP-9 isoforms identification and determination of activities	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Matrix metalloproteinase 9	-	Homo sapiens
MMP-9	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host	up

General Information

General Information	Comment	Organism
additional information	four isoforms of MMP-9 have been reported: the first is a latent form, a zymogen of 92 kDa. The second is obtained by cutting the prodomain of the latent form, resulting in a product of 82 kDa, which produces the active form of the enzyme. The third isoform is a heterodimer that originates from the binding of MMP-9 with the inhibitor TIMP-1, generating a product of 220 kDa. Finally, the fourth isoform corresponds to a 125 kDa heterodimer, made up of MMP-9 associated with lipocalin. Analysis of MMP-9 isoforms identification and determination of activities	Homo sapiens
physiological function	variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection. MMP-9 isoforms might influence the formation and progression of granuloma	Homo sapiens

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Release 2023.1 (January 2023)