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Literature summary for 3.4.24.35 extracted from

  • Ugarte-Berzal, E.; Vandooren, J.; Bailon, E.; Opdenakker, G.; Garcia-Pardo, A.
    Inhibition of MMP-9-dependent degradation of gelatin, but not other MMP-9 substrates, by the MMP-9 hemopexin domain blades 1 and 4 (2016), J. Biol. Chem., 291, 11751-11760 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.35

Inhibitors

Inhibitors Comment Organism Structure
hemopexin domain of MMP-9 the hemopexin domain of MMP-9 inhibits the degradation of gelatin. It also abolishes the degradation of gelatin by MMP-2. Blades 1 and 4 of the PEX9 domain are responsible for the gelatin degradation inhibitory activity of PEX9. The hemopexin domain of MMP-9 does not prevent the degradation of other MMP-9 substrates, such as a fluorogenic peptide, alphaB crystalline, or nonmuscular actin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14780
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNP-Pro-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2 + H2O
-
 Homo sapiens DNP-Pro-cyclohexyl-Ala-Gly + Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
nonmuscular actin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-9
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens