Cloned (Comment) | Organism |
---|---|
gene MMP9, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
gene MMP9, quantitative real-time PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis | Homo sapiens |
additional information | in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | - |
Homo sapiens | |
GM6001 | - |
Mus musculus | |
MMP-9 inhibitor I | - |
Homo sapiens | |
MMP-9 inhibitor I | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
extracellular | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
Gelatin + H2O | Mus musculus | - |
? | - |
? | |
Gelatin + H2O | Mus musculus C57BL/6 x DBA/2 | - |
? | - |
? | |
islet amyloid polypeptide + H2O | Mus musculus | enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | ? | - |
? | |
islet amyloid polypeptide + H2O | Homo sapiens | enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | ? | - |
? | |
islet amyloid polypeptide + H2O | Mus musculus C57BL/6 x DBA/2 | enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14780 | gene MMP9 | - |
Mus musculus | P41245 | gene MMP9 | - |
Mus musculus C57BL/6 x DBA/2 | P41245 | gene MMP9 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic islet | - |
Homo sapiens | - |
pancreatic islet | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Mus musculus | ? | - |
? | |
Gelatin + H2O | - |
Mus musculus C57BL/6 x DBA/2 | ? | - |
? | |
islet amyloid polypeptide + H2O | enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | Mus musculus | ? | - |
? | |
islet amyloid polypeptide + H2O | enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | Homo sapiens | ? | - |
? | |
islet amyloid polypeptide + H2O | enzyme MMP-9 degrades amyloidogenic human islet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide | Mus musculus C57BL/6 x DBA/2 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase | - |
Homo sapiens |
gelatinase | - |
Mus musculus |
matrix metalloproteinase-9 | - |
Homo sapiens |
matrix metalloproteinase-9 | - |
Mus musculus |
MMP9 | - |
Homo sapiens |
MMP9 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects | down |
General Information | Comment | Organism |
---|---|---|
malfunction | in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis | Homo sapiens |
malfunction | in an islet culture model where human islet amyloid polypeptide transgenic mouse islets develop amyloid but nontransgenic islets do not, a broad spectrum MMP inhibitor (GM6001) and an MMP-2/9 inhibitor increases amyloid formation and the resultant beta-cell apoptosis | Mus musculus |
physiological function | because islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects, islet MMP-9 activity may also be decreased in human type 2 diabetes, thereby contributing to increased islet amyloid deposition and beta-cell loss. Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide, the constituent of amyloid deposits in Alzheimer's disease | Homo sapiens |
physiological function | matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide, the constituent of amyloid deposits in Alzheimer's disease | Mus musculus |