Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.35 extracted from

  • Oshitari, T.; Okuyama, Y.; Miyata, Y.; Kosano, H.; Takahashi, H.; Natsugari, H.
    Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production (2011), Bioorg. Med. Chem. Lett., 21, 4540-4544.
    View publication on PubMed
Search for more literature for 3.4.24.35

Inhibitors

Inhibitors Comment Organism Structure
3',4',5,6,7,8-hexamethoxyflavone i.e. nobiletin Homo sapiens
3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
-
 Homo sapiens
3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
-
 Homo sapiens
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
-
 Homo sapiens
additional information synthesis and inhibitory activity against MMP-9 of nobiletin metabolites, overview. The key intermediate is 2'0-hydroxy-3',4',5',6'-tetramethoxyacetophenone Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
lens
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0037
-
 PMA-treated cells, pH and temperature not specified in the publication Homo sapiens 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
0.0055
-
 TNF-alpha-treated cells, pH and temperature not specified in the publication Homo sapiens 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
0.0108
-
 TNF-alpha-treated cells, pH and temperature not specified in the publication Homo sapiens 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
0.0123
-
 PMA-treated cells, pH and temperature not specified in the publication Homo sapiens 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
0.0164
-
 TNF-alpha-treated cells, pH and temperature not specified in the publication Homo sapiens 3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
0.0169
-
 PMA-treated cells, pH and temperature not specified in the publication Homo sapiens 3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
0.017
-
 TNF-alpha-treated cells, pH and temperature not specified in the publication Homo sapiens 3',4',5,6,7,8-hexamethoxyflavone
0.0209
-
 PMA-treated cells, pH and temperature not specified in the publication Homo sapiens 3',4',5,6,7,8-hexamethoxyflavone