Application | Comment | Organism |
---|---|---|
medicine | MMP-9 is a potential target for cerebral ischemic treatment in human stroke therapy | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
activated enzyme | Homo sapiens |
92000 | - |
inactive enzyme form | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Aggrecan core protein + H2O | Homo sapiens | - |
? | - |
? | |
collagen type IV + H2O | Homo sapiens | - |
? | - |
? | |
collagen type V + H2O | Homo sapiens | - |
? | - |
? | |
collagen type XI + H2O | Homo sapiens | - |
? | - |
? | |
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
Laminin + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
cEND cell | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Aggrecan core protein + H2O | - |
Homo sapiens | ? | - |
? | |
collagen type IV + H2O | - |
Homo sapiens | ? | - |
? | |
collagen type V + H2O | - |
Homo sapiens | ? | - |
? | |
collagen type XI + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
Laminin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase B | - |
Homo sapiens |
matrix metalloproteinase-9 | - |
Homo sapiens |
MMP-9 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the antihemorrhagic effect of PJ34, a potent PARP inhibitor, is associated with a 57% decrease in MMP-9 overexpression, glucocorticoid increases TIMP-1 in the brain endothelial cell line cEND to reduce the levels of MMP-9 | down |
Homo sapiens | the expression of MMP-9 is elevated after cerebral ischemia, expression of MMP-9 increases after permanent middle cerebral artery occlusion and transient middle cerebral artery occlusion. interleukin-1beta, tissue necrosis factor-alpha, fibroblast growth facor, and epidermal growth factor can stimulate the secretion of MMP-9 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-9 plays an important role in wound healing, angiogenesis, inflammation, tumor invasion, and metastasis | Homo sapiens |