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Literature summary for 3.4.24.35 extracted from

  • Zhou, L.; Yan, C.; Gieling, R.G.; Kida, Y.; Garner, W.; Li, W.; Han, Y.P.
    Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1 (2009), BMC Immunol., 10, 15.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
interleukin-1
-
Homo sapiens
additional information dermal fibroblasts and hepatic stellate cells require type-I collagen which boosts Jun N-terminal kinase activity to maximally induce MMP-9 Homo sapiens
tumor necrosis factor-alpha
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information MMP-9 is specifically regulated by p21-activated-kinase-1, ectopic expression of p21-activated-kinase-1 variants impairs Jun N-terminal kinase but not necrosis factor-kappaB pathway, which in turn suppresses the promoter activation and transcription of MMP-9 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
92000
-
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal fibroblast
-
Homo sapiens
-
epithelial cell
-
Homo sapiens
-
hepatic stellate cell
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-
mesenchymal cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-9
-
Homo sapiens
MMP-9
-
Homo sapiens