Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1 | - |
Homo sapiens | |
additional information | dermal fibroblasts and hepatic stellate cells require type-I collagen which boosts Jun N-terminal kinase activity to maximally induce MMP-9 | Homo sapiens | |
tumor necrosis factor-alpha | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | MMP-9 is specifically regulated by p21-activated-kinase-1, ectopic expression of p21-activated-kinase-1 variants impairs Jun N-terminal kinase but not necrosis factor-kappaB pathway, which in turn suppresses the promoter activation and transcription of MMP-9 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
92000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dermal fibroblast | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
hepatic stellate cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
mesenchymal cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-9 | - |
Homo sapiens |
MMP-9 | - |
Homo sapiens |