Literature summary for 3.4.24.35 extracted from

Rosenblum, G.; Van den Steen, P.E.; Cohen, S.R.; Grossmann, J.G.; Frenkel, J.; Sertchook, R.; Slack, N.; Strange, R.W.; Opdenakker, G.; Sagi, I.
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B (2007), Structure, 15, 1227-1236.

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Application

Application	Comment	Organism
drug development	MMP-9 is a therapeutic target in autoimmune diseases, vascular pathologies, and cancer	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of full-length pro-MMP-9 in Spodoptera frugiperda Sf9 cells	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	a zinc endopeptidase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	MMP-9 contains a heavily O-glycosylated OG domain	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
recombinant full-length pro-MMP-9 from Spodoptera frugiperda Sf9 cells	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	varied enzyme conformations and in facilitating independent movements of the terminal domains may endorse recognition, binding, and processing of substrates, ligands, as well as receptors and marks this domain as an additional target for the design of selective regulators, overview	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
dimer	dimers of MMP-9 are detected under physiological conditions	Homo sapiens
More	the recombinant enzyme forms mixtures of monomers and other higher oligomeric species, structural model of multidomain full-length pro-MMP-9, including the unique proline-rich and heavily O-glycosylated OG domain, combining small-angle X-ray scattering with single-molecule atomic force microscopy imaging to characterize a full-length structural model of pro-MMP-9, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
matrix metalloproteinase-9	-	Homo sapiens
MMP-9	-	Homo sapiens
pro-matrix metalloproteinase-9	-	Homo sapiens

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Release 2023.1 (January 2023)