Literature summary for 3.4.24.35 extracted from

Shimanovich, I.; Mihai, S.; Oostingh, G.J.; Ilenchuk, T.T.; Broecker, E.B.; Opdenakker, G.; Zillikens, D.; Sitaru, C.
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid (2004), J. Pathol., 204, 519-527.

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Application

Application	Comment	Organism
medicine	enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin. Selective inhibition of enzyme by single-chain variable fragment of a monoclonal antibody results in suppression of blistering	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	patients with epidermolysis bullosa acquisita and bullous pemphigoid	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme and leucocyte elastase are essential for granulocyte-mediated proteolysis resulting in dermal-epidermal separation in epidermolysis bullosa acquisita and bullous pemphigoid patients skin	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)