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Literature summary for 3.4.24.35 extracted from

  • Van den Steen, P.E.; Proost, P.; Brand, D.D.; Kang, A.H.; Van Damme, J.; Opdenakker, G.
    Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B (2004), Biochemistry, 43, 10809-10816.
    View publication on PubMed
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Application

Application Comment Organism
medicine neutrophils of patients with rheumatoid arthritis release considerable amounts of enzyme. Enzyme acts on fragments of collagen type II obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes. Lysines in the main immunodominant epitope are modified by partial hydroxylation and partial glycosylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fragments of human collagen type II + H2O fragments obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes Homo sapiens ?
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 ?