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Literature summary for 3.4.24.34 extracted from

  • Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
    Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9 (2019), Nat. Prod. Res., 33, 1765-1768 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
isovitexin interacts with enzyme residues Val112, Ser218, Leu119, Glu118, Asn226, Ser225, Thr224, Asn184, Phe192, and Asp115, binding structure analysis, and modelling, overview Homo sapiens
additional information Ficus deltoidea leaf extract inhibits matrix metalloproteinase-2, 8 and 9, molecular docking, molecular dynamics, molecular dynamic simulation analysis , overview. Computational docking analysis reveals that vitexin and isovitexin binds to the active site of the three tested MMPs Homo sapiens
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid NNGH Homo sapiens
vitexin interacts with enzyme residues Leu193, Tyr219, Ala161, Asn218, His207, Glu198, Gly158, Pro217, His201, and Val194, binding structure analysis, and modelling, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P22894
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-
EAhy 926 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-8
-
Homo sapiens
MMP-8
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens