Literature summary for 3.4.24.34 extracted from

Lee, E.; Han, J.; Woo, M.; Shin, J.; Park, E.; Kang, J.; Moon, P.; Baek, M.; Son, W.; Ko, Y.; Choi, J.; Kim, H.
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation (2014), J. Immunol., 193, 2384-2393.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P22894	-	-
Mus musculus	O70138	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-
commercial preparation	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
TNF-alpha + H2O	-	Homo sapiens	?	MMP8 exhibits TNF-alpha-converting enzyme activity by cleaving the prodomain of TNF-alpha at residues A74-Q75 and A76-V77	?

General Information

General Information	Comment	Organism
physiological function	MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia, and treatment with MMP-8 inhibitor or MMP-8 short hairpin RNA suppresses proinflammatory molecules, particularly TNF-alpha secretion. Treatment with MMP-8 inhibitor inhibits TNF-alpha-converting enzyme activity more efficiently than TAPI-0, a general TNF-alpha converting enzyme inhibitor. It inhibits MAPK phosphorylation, NF-kappaB/AP-1 activity, and reactive oxygen species production	Homo sapiens
physiological function	MMP-8 is upregulated in septic conditions, particularly in microglia. Administration of MMP-8 inhibitor or MMP-8 short hairpin RNA significantly inhibits microglial activation and expression/secretion of TNF-alpha in brain tissue, serum, and cerebrospinal fluid of lipopolysaccharid-induced septic mice	Mus musculus

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Release 2023.1 (January 2023)