Protein Variants | Comment | Organism |
---|---|---|
additional information | polymorphonuclear cell infiltration towards lipopolysaccharides is abrogated in MMP-8-null mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MMP-8 hemopexin C-domain | recombinantly expressed, in excess inhibits the processing of LIX cytokine by blocking the binding site, overview | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 | Mus musculus |
85000 | - |
x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
epithelial cell-derived neutrophil activating peptide-78 + H2O | Mus musculus | i.e. ENA-78, or CXCL5, a cytokine | ? | - |
? | |
interleukin-8 + H2O | Mus musculus | - |
? | - |
? | |
LIX + H2O | Mus musculus | a murine ELR+ CXC chemokine | ? | - |
? | |
additional information | Mus musculus | lipopolysaccharide responsiveness and neutrophil chemotaxis in vivo require polymorphonuclear MMP-8 activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the pro-MMP-8 is processed to its active form | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | lipopolysacchride-treated | Mus musculus | - |
leukocyte | - |
Mus musculus | - |
polymorphonuclear cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
epithelial cell-derived neutrophil activating peptide-78 + H2O | i.e. ENA-78, or CXCL5, a cytokine | Mus musculus | ? | - |
? | |
interleukin-8 + H2O | - |
Mus musculus | ? | - |
? | |
LIX + H2O | a murine ELR+ CXC chemokine | Mus musculus | ? | - |
? | |
LIX + H2O | a murine ELR+ CXC chemokine, MMP-8 cleaves the 92-amino acid peptide LIX between Ser-Val at position 4-5 to generate a NH2-terminus at Val5 designated LIX (5-92), the binding site is located on the MMP-8 hemopexin C-domain | Mus musculus | ? | - |
? | |
additional information | lipopolysaccharide responsiveness and neutrophil chemotaxis in vivo require polymorphonuclear MMP-8 activity, overview | Mus musculus | ? | - |
? | |
additional information | no activity with the murine ELR+ CXC chemokines KC, MIP-2, and DCIP-1 | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 85000, Pro-MMP-8, x * 65000, active mature MMP-8 | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
Matrix metalloproteinase-8 | - |
Mus musculus |
MMP-8 | - |
Mus musculus |
polymorphonuclear leukocyte collagenase | - |
Mus musculus |