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Literature summary for 3.4.24.34 extracted from

  • Graf von Roedern, E.; Brandstetter, H.; Engh, R.A.; Bode, W.; Grams, F.; Moroder, L.
    Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8) (1998), J. Med. Chem., 41, 3041-3047.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2R,S)-HONH-Mal(Me/Bn)-1,2,9,10-tetrahydroisoquinolide
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-alpha-naphthylamide
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2-Ph
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2-Ph
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2CH2-Ph
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NHBn
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NHBn-(p-COOH)
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-NHPh
-
Homo sapiens
(2R,S)-HONH-Mal(Me/Bn)-Oet
-
Homo sapiens
(2R,S)-HONH-Mal(Me/i-Bu)-Oet
-
Homo sapiens
(2R,S)-HONH-Mal(NHAc/Bn)-NHBn
-
Homo sapiens
(2R,S)-HONH-Mal(OH/Bn)-NHBn
-
Homo sapiens
malonic acid hydroxamate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Synonyms

Synonyms Comment Organism
MMP8
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00024
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2-Ph pH 7.6, 25°C Homo sapiens
0.00038
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2CH2CH2-Ph pH 7.6, 25°C Homo sapiens
0.0011
-
(2R,S)-HONH-Mal(Me/Bn)-NHBn pH 7.6, 25°C Homo sapiens
0.0019
-
(2R,S)-HONH-Mal(OH/Bn)-NHBn pH 7.6, 25°C Homo sapiens
0.0023
-
(2R,S)-HONH-Mal(NHAc/Bn)-NHBn pH 7.6, 25°C Homo sapiens
0.0081
-
(2R,S)-HONH-Mal(Me/Bn)-1,2,9,10-tetrahydroisoquinolide pH 7.6, 25°C Homo sapiens
0.0096
-
(2R,S)-HONH-Mal(Me/Bn)-NH-CH2CH2-Ph pH 7.6, 25°C Homo sapiens
0.011
-
(2R,S)-HONH-Mal(Me/Bn)-Oet pH 7.6, 25°C Homo sapiens
0.041
-
(2R,S)-HONH-Mal(Me/i-Bu)-Oet pH 7.6, 25°C Homo sapiens
0.041
-
(2R,S)-HONH-Mal(Me/Bn)-NHBn-(p-COOH) pH 7.6, 25°C Homo sapiens
0.044
-
(2R,S)-HONH-Mal(Me/Bn)-NHPh pH 7.6, 25°C Homo sapiens
0.045
-
(2R,S)-HONH-Mal(Me/Bn)-alpha-naphthylamide pH 7.6, 25°C Homo sapiens