Literature summary for 3.4.24.34 extracted from

Fosang, A.J.; Last, K.; Neame, P.J.; Murphy, G.; Kn�uper, S.; Tschesche, H.; Hughes, C.E.; Caterson, B.; Hardingham, T.E.
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan (1994), Biochem. J., 304, 347-351.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	-	Homo sapiens
EDTA	-	Homo sapiens
Ile-Pro-Glu-Asn-Phe-Phe-Gly	aggrecan as substrate	Homo sapiens
additional information	no inhibition by PMSF, pepstatin, N-ethylmaleimide, cystatin or E-64	Homo sapiens
Thr-Glu-Gly-Glu-Ala-Arg-Gly	aggrecan as substrate	Homo sapiens
Tissue inhibitor of metalloproteinase-I	i.e. TIMP-I	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	neutrophil	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cartilage aggrecan + H2O	cleavage at Glu373-Ala374 "aggrecanase" site in intraglobular domain	Homo sapiens	hydrolyzed cartilage aggrecan	-	?

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Release 2023.1 (January 2023)