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Literature summary for 3.4.24.30 extracted from

  • Mäkinen, P.L.; Mäkinen, K.K.
    The Enterococcus faecalis extracellular metalloendopeptidase (EC 3.4.24.30; coccolysin) inactivates human endothelin at bonds involving hydrophobic amino acid residues (1994), Biochem. Biophys. Res. Commun., 200, 981-985.
    View publication on PubMed
Search for more literature for 3.4.24.30

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Enterobacter faecalis
-
-
soluble
-
 Enterobacter faecalis
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Endothelin 1 + H2O Enterobacter faecalis presumably involved in initiation and propagation of Enterobacter faecalis associated inflammations, destroys biological activity of endothelin 1 ?
-
 ?
Endothelin 1 + H2O Enterobacter faecalis OG1-10 presumably involved in initiation and propagation of Enterobacter faecalis associated inflammations, destroys biological activity of endothelin 1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Enterobacter faecalis
-
 OG1-10
-
Enterobacter faecalis OG1-10
-
 OG1-10
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Azocoll + H2O general protease substrate Enterobacter faecalis ?
-
 ?
Azocoll + H2O general protease substrate Enterobacter faecalis OG1-10 ?
-
 ?
Big endothelin-1 + H2O human, cleavage sites: Ser5-Leu6 and His16-Leu17 Enterobacter faecalis ?
-
 ?
Big endothelin-1 + H2O human, cleavage sites: Ser5-Leu6 and His16-Leu17 Enterobacter faecalis OG1-10 ?
-
 ?
Big endothelin-1 fragment(22-38) + H2O
-
 Enterobacter faecalis Hydrolyzed fragment of big endothelin fragment peptides (Val22-Val28) and (Val29-Gly32) and (Leu33-Ser38) ?
Big endothelin-1 fragment(22-38) + H2O
-
 Enterobacter faecalis OG1-10 Hydrolyzed fragment of big endothelin fragment peptides (Val22-Val28) and (Val29-Gly32) and (Leu33-Ser38) ?
Endothelin 1 + H2O presumably involved in initiation and propagation of Enterobacter faecalis associated inflammations, destroys biological activity of endothelin 1 Enterobacter faecalis ?
-
 ?
Endothelin 1 + H2O presumably involved in initiation and propagation of Enterobacter faecalis associated inflammations, destroys biological activity of endothelin 1 Enterobacter faecalis OG1-10 ?
-
 ?
Human endothelin-1 + H2O primary cleavage at Ser5-Leu6, subsequent hydrolysis of His16-Leu17, degradation resembles processing by thermolysin, identification of products Enterobacter faecalis ?
-
 ?
Human endothelin-1 + H2O primary cleavage at Ser5-Leu6, subsequent hydrolysis of His16-Leu17, degradation resembles processing by thermolysin, identification of products Enterobacter faecalis OG1-10 ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Enterobacter faecalis