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Literature summary for 3.4.24.29 extracted from

  • Martiญ, M.; Trotonda, M.; Tormo-Mas, M.; Vergara-Irigaray, M.; Cheung, A.; Lasa, I.; Penades, J.
    Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus (2010), Microbes Infect., 12, 55-64.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Staphylococcus aureus
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Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bap + H2O Staphylococcus aureus a surface-anchored protein ?
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 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bap + H2O a surface-anchored protein Staphylococcus aureus ?
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 ?

General Information

General Information Comment Organism
malfunction the sigB mutant strain overexpresses the surface-anchored protein Bap, that is essential for biofilm formation in the model strain. Staphylococcus aureus completely inhibits the biofilm formation of the mutant strain via Aur and SspA, two proteases that are overexpressed in the sigB mutant strain and are capable of degrading Bap Staphylococcus aureus
physiological function extracellular proteases Aur and SspA inhibit protein-dependent biofilm formation by Staphylococcus aureus, detailed overview Staphylococcus aureus