Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of transgenic C57BL/6 mice overexpressing human MMP2, phenotype, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Homo sapiens | |
Zn2+ | metalloproteinase | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08253 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | circulating hMMP2is significantly increased in diabetic patients compared to controls and significantly correlated with the serum C-peptide levels | Homo sapiens | - |
pancreatic islet | beta-cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | induction of diabetes in transgenic mice overexpressing human MMP2 show ignificant improvements in glycemia, glucose tolerance and insulin secretion compared to diabetic wild-type mice. Increased hMMP2 levels in mice correlate with significant reduction in islet beta-cell apoptosis compared to wild-type counterparts, and an inhibitor of hMMP2 reverses this mitigating activity against diabetes | Homo sapiens |
physiological function | chronic progression of diabetes is associated with decreased pancreatic islet mass due to apoptosis of beta-cells. Patients with diabetes have increased circulating matrix metalloproteinase-2 (MMP2). MMP2 might inhibit cell apoptosis, including islet beta-cells. The increased activation of Akt and BAD induced by hMMP2 in beta-cells compared to controls, links this signaling pathway to the anti-apoptotic activity of hMMP2, a property that is reversible by both an hMMP2 inhibitor and antibody against integrin-beta3. hMMP2 may attenuate the severity of diabetes by protecting islet beta-cells from apoptosis through an integrin-mediated activation of the Akt/BAD pathway. Preliminary treatment of cells, e.g. HepG2 cells, HUVE cells, and NHM cells, with active hMMP2 for 30-min significantly inhibits apoptosis (induced by starvation), hMMP2 inhibits apoptosis of beta-cell lines, which is modulated by intergrins | Homo sapiens |