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Literature summary for 3.4.24.24 extracted from

  • Momi, S.; Falcinelli, E.; Giannini, S.; Ruggeri, L.; Cecchetti, L.; Corazzi, T.; Libert, C.; Gresele, P.
    Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo (2009), J. Exp. Med., 206, 2365-2379.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

General Stability

General Stability Organism
the plasmatic half-life of human recombinant pro-MMP-2, assessed after the intravenous injection of 500 ng of the proenzyme in MMP-2-deficient mice is 19 min Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet human platelets contain matrix metalloproteinase 2 and release it upon activation Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-2
-
 Homo sapiens
MMP-2
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the inactivation of the MMP-2 gene prevents thrombosis induced by weak, but not strong, stimuli but produces only a moderate prolongation of the bleeding time. MMP-2 deficient mice have hyporeactive platelets, a defective thrombotic response and mildly impaired hemostasis Homo sapiens
physiological function platelet-derived MMP-2 facilitates thrombus formation Homo sapiens