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Literature summary for 3.4.24.24 extracted from

  • Emara, M.; Cheung, P.Y.
    Inhibition of sulfur compounds and antioxidants on MMP-2 and -9 at the activity level found during neonatal hypoxia-reoxygenation (2006), Eur. J. Pharmacol., 544, 168-173.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ascorbic acid
-
Sus scrofa
GSH
-
Homo sapiens
GSH
-
Sus scrofa
GSSG
-
Homo sapiens
GSSG
-
Sus scrofa
L-ascorbic acid
-
Homo sapiens
L-cysteine
-
Homo sapiens
L-cysteine
-
Sus scrofa
L-histidine
-
Homo sapiens
L-histidine
-
Sus scrofa
L-homocysteine
-
Homo sapiens
L-homocysteine
-
Sus scrofa
L-methionine
-
Homo sapiens
L-methionine
-
Sus scrofa
additional information inhibition potency of sulfur-containing compounds, overview Homo sapiens
additional information inhibition potency of sulfur-containing compounds, overview Sus scrofa
N-acetylcysteine
-
Homo sapiens
N-acetylcysteine
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
newborn undergoing hypoxia and reoxygenation
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low activity Sus scrofa
-
commercial preparation recombinant enzyme Homo sapiens
-
left ventricle
-
Sus scrofa
-
liver
-
Sus scrofa
-
lung high activity Sus scrofa
-
additional information MMP-2 activity in tissues taken from newborn piglets undergoing hypoxia and reoxygenation, overview Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O gelatin zymography Homo sapiens ?
-
?
Gelatin + H2O gelatin zymography Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
MMP-2
-
Homo sapiens
MMP-2
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.061
-
recombinant enzyme Homo sapiens L-cysteine
0.118
-
recombinant enzyme Homo sapiens L-histidine
0.141
-
recombinant enzyme Homo sapiens ascorbic acid
0.195
-
recombinant enzyme Homo sapiens GSH
0.547
-
recombinant enzyme Homo sapiens GSSG
0.727
-
recombinant enzyme Homo sapiens L-homocysteine
1
-
recombinant enzyme Homo sapiens N-acetylcysteine
8.68
-
recombinant enzyme Homo sapiens L-methionine