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Literature summary for 3.4.24.24 extracted from

  • Rosenblum, G.; Meroueh, S.O.; Kleifeld, O.; Brown, S.; Singson, S.P.; Fridman, R.; Mobashery, S.; Sagi, I.
    Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2) (2003), J. Biol. Chem., 278, 27009-27015.
    View publication on PubMed
Search for more literature for 3.4.24.24

Application

Application Comment Organism
medicine inhibitors for use as potential therapeutic agents Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme from HeLa S3 cells infected with vaccinia virus encoding the full-length cDNA of pro-MMP-2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-(4-phenoxphenylsulfonyl)butane-1,2-dithiol
-
 Homo sapiens
5-(4-phenoxphenylsulfonyl)pentane-1,2-dithiol
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent gelatinase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
extracellular matrix components + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens plays a key role in angiogenesis and tumor metastasis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08253 human
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from HeLa S3 cells, native enzyme purified from HT-1080 cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
extracellular matrix components + H2O
-
 Homo sapiens ?
-
 ?
additional information plays a key role in angiogenesis and tumor metastasis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase A
-
 Homo sapiens
human matrix metalloproteinase-2
-
 Homo sapiens
MMP-2
-
 Homo sapiens