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Literature summary for 3.4.24.24 extracted from

  • Chen, E.I.; Kridel, S.J.; Howard, E.W.; Li, W.; Godzik, A.; Smith, J.W.
    A unique substrate recognition profile for matrix metalloproteinase-2 (2002), J. Biol. Chem., 277, 4485-4491.
    View publication on PubMed
Search for more literature for 3.4.24.24

Inhibitors

Inhibitors Comment Organism Structure
TIMP-2
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
 peptide A13R pH 7.5, 37°C Homo sapiens
0.4
-
 peptide A13P pH 7.5, 37°C Homo sapiens
0.6
-
 peptide B74P pH 7.5, 37°C Homo sapiens
0.8
-
 peptide B74R pH 7.5, 37°C Homo sapiens
1.3
-
 peptide A13 pH 7.5, 37°C Homo sapiens
2.2
-
 peptide A34 pH 7.5, 37°C Homo sapiens
2.2
-
 peptide B74 pH 7.5, 37°C Homo sapiens
2.4
-
 peptide B37 pH 7.5, 37°C Homo sapiens
3.2
-
 peptide A21A pH 7.5, 37°C Homo sapiens
3.6
-
 peptide A3 pH 7.5, 37°C Homo sapiens
4.4
-
 peptide C9 pH 7.5, 37°C Homo sapiens
4.5
-
 peptide B49 pH 7.5, 37°C Homo sapiens
6.4
-
 peptide C9R pH 7.5, 37°C Homo sapiens
7.7
-
 peptide A21 pH 7.5, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens important role in tumor angiogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
catalytic domain Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ephB1 + H2O
-
 Homo sapiens ?
-
 ?
additional information important role in tumor angiogenesis Homo sapiens ?
-
 ?
peptide A13 + H2O
-
 Homo sapiens ?
-
 ?
peptide A13P + H2O
-
 Homo sapiens ?
-
 ?
peptide A13R + H2O
-
 Homo sapiens ?
-
 ?
peptide A21 + H2O
-
 Homo sapiens ?
-
 ?
peptide A21A + H2O
-
 Homo sapiens ?
-
 ?
peptide A3 + H2O
-
 Homo sapiens ?
-
 ?
peptide A34 + H2O
-
 Homo sapiens ?
-
 ?
peptide B37 + H2O
-
 Homo sapiens ?
-
 ?
peptide B49 + H2O
-
 Homo sapiens ?
-
 ?
peptide B74 + H2O
-
 Homo sapiens ?
-
 ?
peptide B74P + H2O
-
 Homo sapiens ?
-
 ?
peptide B74R + H2O
-
 Homo sapiens ?
-
 ?
peptide C9 + H2O
-
 Homo sapiens ?
-
 ?
peptide C9R + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
gelatinase A
-
 Homo sapiens
matrix metalloproteinase-2
-
 Homo sapiens
MMP-2
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2 8 peptide A13R pH7.5, 37°C Homo sapiens
61
-
 peptide B74R pH7.5, 37°C Homo sapiens
105
-
 peptide A13 pH7.5, 37°C Homo sapiens
124
-
 peptide A21 pH7.5, 37°C Homo sapiens
202
-
 peptide A34 pH7.5, 37°C Homo sapiens
204
-
 peptide A13P pH7.5, 37°C Homo sapiens
264
-
 peptide B74P pH7.5, 37°C Homo sapiens
353
-
 peptide B37 pH7.5, 37°C Homo sapiens
400
-
 peptide A3 pH7.5, 37°C Homo sapiens
510
-
 peptide B49 pH7.5, 37°C Homo sapiens
601
-
 peptide A21A pH7.5, 37°C Homo sapiens
622
-
 peptide B74 pH7.5, 37°C Homo sapiens
740
-
 peptide C9 pH7.5, 37°C Homo sapiens