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Literature summary for 3.4.24.24 extracted from
- X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme (2001), J. Biol. Chem., 276, 17125-17131.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | understanding the detailed molecular structures and the comformational changes of MMP-2 in its zymogen, active, and inhibited states can aid in the rational design of anti-cancer drugs | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| pro-MMP-2 expressed in a recombinant vaccinia virus mammalian cell expression system | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SB-3CT | mechanism-based synthetic inhibitor | Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc-dependent endopeptidase | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | facilitates tmumor metastasis and angiogenesis by hydrolyzing components of the extracwllular matrix | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P08253 | human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | facilitates tmumor metastasis and angiogenesis by hydrolyzing components of the extracwllular matrix | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gelatinase A | - |
Homo sapiens |
| human matrix metalloproteinase-2 | - |
Homo sapiens |
| MMP-2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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