Application | Comment | Organism |
---|---|---|
medicine | understanding the detailed molecular structures and the comformational changes of MMP-2 in its zymogen, active, and inhibited states can aid in the rational design of anti-cancer drugs | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
pro-MMP-2 expressed in a recombinant vaccinia virus mammalian cell expression system | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SB-3CT | mechanism-based synthetic inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-dependent endopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | facilitates tmumor metastasis and angiogenesis by hydrolyzing components of the extracwllular matrix | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08253 | human | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | facilitates tmumor metastasis and angiogenesis by hydrolyzing components of the extracwllular matrix | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase A | - |
Homo sapiens |
human matrix metalloproteinase-2 | - |
Homo sapiens |
MMP-2 | - |
Homo sapiens |