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Literature summary for 3.4.24.23 extracted from

  • Li, M.; Zhang, Y.; Tian, H.; Zheng, M.; Yang, M.; Fang, H.; Xie, Y.; Jin, J.
    Nitro-based selective inhibitors against matrix metalloproteinase-7 over matrix metalloproteinase-1 (2015), RSC Adv., 5, 104725-104732 .
No PubMed abstract available
Search for more literature for 3.4.24.23

Inhibitors

Inhibitors Comment Organism Structure
additional information nitro-based selective inhibitors against matrix metalloproteinase-7, overview. Kinetics and active-site-binding mode of the inhibitors, molecular docking. A reasonable adjustment of the P'3 side chains of the nitro-based MMP inhibitors could improve selectivity for the inhibition of MMP-7 over MMP-1 (EC 3.4.24.7) Homo sapiens
[(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1'',1'')-diphenyl]-methylamide
-
 Homo sapiens
[(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1''R)-phenyl]-ethylamide
-
 Homo sapiens
[(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1''S)-phenyl]-ethylamide
-
 Homo sapiens
[(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucylmethylamide
-
 Homo sapiens
[(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucylphenylamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens
Zn2+ a zinc-dependent metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
 Homo sapiens
-
commercial preparation recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetic analysis Homo sapiens
0.0000037
-
 [(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1''S)-phenyl]-ethylamide pH 7.5, 37°C, recombinant enzyme Homo sapiens
0.0000089
-
 [(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1''R)-phenyl]-ethylamide pH 7.5, 37°C, recombinant enzyme Homo sapiens
0.0000094
-
 [(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucylphenylamide pH 7.5, 37°C, recombinant enzyme Homo sapiens
0.0000148
-
 [(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucyl-[(1'',1'')-diphenyl]-methylamide pH 7.5, 37°C, recombinant enzyme Homo sapiens
0.000158
-
 [(2'R,3'S)-2'-iso-butyl-3'-hydroxy-4'-nitro]butyryl-(S)-tert-leucylmethylamide pH 7.5, 37°C, recombinant enzyme Homo sapiens