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Literature summary for 3.4.24.23 extracted from

  • Garalla, H.M.; Lertkowit, N.; Tiszlavicz, L.; Reisz, Z.; Holmberg, C.; Beynon, R.; Simpson, D.; Varga, A.; Kumar, J.D.; Dodd, S.; Pritchard, D.M.; Moore, A.R.; Rosztoczy, A.I.; Wittman, T.; Simpson, A.; Dockray, G.J.; Varro, A.
    Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma expression, metabolism, and functional significance (2018), Physiol. Rep., 6, e13683 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene MMP7, quantitative real-time PCR enzyme expression and analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information MMP-7 siRNA-mediated knockdown and immunoneutralization of MMP-7 in OE33 cells causes increased migration and invasion in response to conditioned media of myofibroblasts Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information Expression of proMMP-7 but not secretion in myofibroblasts Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens
Zn2+ a zinc-dependent metalloproteinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
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-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell predominantly expressed Homo sapiens
-
esophageal adenocarcinoma cell
-
 Homo sapiens
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esophagus
-
 Homo sapiens
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additional information immunohistochemic analysis Homo sapiens
-
myofibroblast esophageal, expression of proMMP-7 but not secretion in myofibroblasts Homo sapiens
-
OE-33 cell high constitutive secretion of proMMP-7 in the EAC cell line, dependent on phosphatidylinositol (PI) 3-kinase, inhibited by PI 3-kinase inhibitor LY294002 but not by inhibitors of protein kinase C, or MAP kinase activation Homo sapiens
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Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
MMP-7
-
 Homo sapiens
PUMP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction myofibroblasts exhibit increased migration and invasion in response to conditioned media from OE33 cells that is reduced by MMP-7 knockdown and immunoneutralization Homo sapiens
metabolism possible metabolism of MMP-7 by myofibroblasts studied by proteomic analysis indicates degradation via extensive endopeptidase, followed by amino- and carboxpeptidase, cleavages Homo sapiens
physiological function increased expression of MMP-7 in the progression to cancer. MMP-7 expression increases at the invasive front in esophageal adenocarcinoma (EAC), which may be partly attributable to activation of phosphatidylinositol 3-kinase. Secreted MMP-7 may modify the tumor microenvironment by stimulating stromal cell migration and invasion Homo sapiens