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Literature summary for 3.4.24.23 extracted from

  • Fu, H.; Zhou, D.; Zhu, H.; Liao, J.; Lin, L.; Hong, X.; Hou, F.F.; Liu, Y.
    Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration (2019), Kidney Int., 95, 1167-1180 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Application

Application Comment Organism
diagnostics matrix metalloproteinase-7 (MMP-7) is an early and valuable biomarker for predicting severe acute kidney injury (AKI) and poor outcomes in patients after cardiac surgery Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of MMP-7 knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
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-
extracellular the enzyme is secreted Mus musculus
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additional information MMP-7 is one of the smallest MMPs, and it is synthesized as an inactive zymogen Mus musculus
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ a zinc- and calcium-dependent endopeptidase Mus musculus
Zn2+ a zinc- and calcium-dependent endopeptidase Mus musculus
Zn2+ a zinc-dependent metalloproteinase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
casein + H2O Mus musculus degradation ?
-
 ?
E-cadherin + H2O Mus musculus ectodomain shedding ?
-
 ?
Fibronectin + H2O Mus musculus degradation ?
-
 ?
Gelatin + H2O Mus musculus degradation ?
-
 ?
Proteoglycan + H2O Mus musculus degradation ?
-
 ?
tumor necrosis factor-alpha + H2O Mus musculus activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09237
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-
Mus musculus Q10738
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-7 is one of the smallest MMPs, and it is synthesized as an inactive zymogen. Upon activation, the N-terminal pro-region is removed through proteolysis, which results in the final active enzyme Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
kidney MMP-7 is induced in renal tubules following ischemia/reperfusion injury or cisplatin administration, and in folic acid-induced acute kidney injury (AKI) Homo sapiens
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kidney MMP-7 is induced in renal tubules following ischemia/reperfusion injury or cisplatin administration, and in folic acid-induced acute kidney injury (AKI) Mus musculus
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renal tubule
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O degradation Mus musculus ?
-
 ?
E-cadherin + H2O ectodomain shedding Mus musculus ?
-
 ?
Fibronectin + H2O degradation Mus musculus ?
-
 ?
Gelatin + H2O degradation Mus musculus ?
-
 ?
additional information MMP-7 is an endopeptidase that degrades a broad range of substrates Homo sapiens ?
-
 ?
additional information MMP-7 is an endopeptidase that degrades a broad range of substrates Mus musculus ?
-
 ?
Proteoglycan + H2O degradation Mus musculus ?
-
 ?
tumor necrosis factor-alpha + H2O activation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase-7
-
 Homo sapiens
Matrix metalloproteinase-7
-
 Mus musculus
MMP-7
-
 Homo sapiens
MMP-7
-
 Mus musculus

General Information

General Information Comment Organism
malfunction MMP-7 knockout mice experience higher mortality, elevated serum creatinine, and more severe histologic lesions after ischemic or toxic insults. Tubular apoptosis and interstitial inflammation are more prominent in MMP-7 knockout kidneys, accompanied by increased expression of FasL and other components of the extrinsic apoptotic pathway, as well as increased expression of pro-inflammatory chemokines. Ablation of MMP-7 promotes tubular cell apoptosis after acute kidney injury (AKI) augmenting renal inflammation, phenotype, overview. Exogenous MMP-7 ameliorates kidney injury in MMP-7 knockout mice after ischemia/reperfusion, mechanism underlying renal protection of MMP-7 in AKI. MMP-7 augmentes c-fos and PCNA expression induced by mitogens-rich serum in renal tubules ex vivo Mus musculus
physiological function the primary function of MMP-7 is to break down the extracellular matrix by digesting casein, gelatins, fibronectin, and proteoglycan. MMP-7 is also capable of cleaving other substrates and plays a role in E-cadherin ectodomain shedding, tumor necrosis factor-alpha (TNF-alpha) release, and activation of other proteinases. Exogenous MMP-7 ameliorates kidney injury in MMP-7 knockout mice after ischemia/reperfusion. In vitro, MMP-7 protects tubular epithelial cells against apoptosis by directly degrading FasL. In isolated tubules ex vivo, MMP-7 promotes cell proliferation by degrading E-cadherin and thereby liberating beta-catenin, priming renal tubules for regeneration. Mechanism underlying renal protection of MMP-7 in acute kidney injury (AKI), overview Mus musculus