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Literature summary for 3.4.24.23 extracted from

  • Rims, C.; McGuire, J.
    Matrilysin (MMP-7) catalytic activity regulates beta-catenin localization and signaling activation in lung epithelial cells (2014), Exp. Lung Res., 40, 126-136.
    View publication on PubMed
Search for more literature for 3.4.24.23

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q10738
-
-
Mus musculus C57BL/6 Q10738
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Mus musculus
-
lung adenocarcinoma cell
-
 Mus musculus
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lung epithelial cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
MMP-7
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme expression is increased in epithelium by bacterial infection, inflammation, fibrosis, and in a lot of carcinomas up

General Information

General Information Comment Organism
malfunction MMP-7-deficient mice show educed beta-catenin activation after lung injury or bleomycin treatment Mus musculus
physiological function the enzyme functions to degrade extracellular matrix and other pericellular substrates including the adherens junction protein E-cadherin to promote wound healing and tissue remodeling. Matrilysin's catalytic activity regulates beta-catenin localization and signaling activation in lung epithelial cells, the enzyme activity releases beta-catenin from the cell membrane after which it is degraded in the cytosol. Matrilysin activity also increases beta-catenin translocation in the presence of a Wnt activating signal Mus musculus