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Literature summary for 3.4.24.23 extracted from

  • Miyake, T.; Yasukawa, K.; Inouye, K.
    Analysis of the mechanism of inhibition of human matrix metalloproteinase 7 (MMP-7) activity by green tea catechins (2011), Biosci. Biotechnol. Biochem., 75, 1564-1569.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(-)-catechin-3-gallate inhibition is un affected by presence of 10 mM CaCl2 Homo sapiens
(-)-epicatechin-3-gallate inhibition is un affected by presence of 10 mM CaCl2 Homo sapiens
(-)-epigallocatechin-3-gallate inhibitory effect is increased on presence of 10 mM CaCl2, no interaction with Cl- Homo sapiens
(-)-gallocatechin-3-gallate inhibitory effect is increased on presence of 10 mM CaCl2, no interaction with Cl- Homo sapiens
additional information green tea catechins inhibit MMP-7 competitively and the galloyl group is essential, differences result from the B-ring, mechanism of inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme from Escherichia coli Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Gly-Leu-[N-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]-L-Ala-L-Arg amide + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 7
-
Homo sapiens
MMP-7
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5 assay at Homo sapiens