Literature summary for 3.4.24.23 extracted from

Scherer, R.L.; VanSaun, M.N.; McIntyre, J.O.; Matrisian, L.M.
Optical imaging of matrix metalloproteinase-7 activity in vivo using a proteolytic nanobeacon (2009), Mol. Imaging, 7, 118-131.

Search for more literature for 3.4.24.23

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adenocarcinoma cell	high MMP-7 expression level	Homo sapiens	-
colonic cancer cell	-	Homo sapiens	-
intestine	-	Homo sapiens	-
SW-480 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cy5.5-M7 peptide + H2O	method development for in vivo detection and quantitation of MMP7 activity, in tumors induces in nude mice by injection of human SW480 colon cancer cells, using a specific near-infrared polymer-based proteolytic beacon, PB-M7NIR. PB-M7NIR is a pegylated polyamidoamine PAMAM-Generation 4 dendrimer core covalently coupled to a Cy5.5 labeled peptide representing a selective substrate that monitors MMP7 activity and AF750 as an internal reference to monitor relative substrate concentration. In vivo imaging of tumors expressing MMP7 has a median S/R ratio 2.2-fold higher than a bilateral control tumor, quantitative detection method with ability of substrate PB-M7NIR to effectively localize and assess MMP7 activity in the tumor microenvironment, development and evaluation, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Matrix metalloproteinase-7	-	Homo sapiens
MMP7	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	matrix metalloproteinases are extracellular proteolytic enzymes involved in tumor progression	Homo sapiens

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Release 2023.1 (January 2023)