Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.23 extracted from

  • Tilakaratne, W.M.; Kobayashi, T.; Ida-Yonemochi, H.; Swelam, W.; Yamazaki, M.; Mikami, T.; Alvarado, C.G.; Shahidul, A.M.; Maruyama, S.; Cheng, J.; Saku, T.
    Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers (2009), J. Oral Pathol. Med., 38, 348-355.
    View publication on PubMed

Application

Application Comment Organism
diagnostics MMP-7 immunohistochemistry may be a valuable aid for identification of the cell proliferation center in oral carcinoma in situ and dysplasia Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell carcinoma in situ, MMP-7+ cells are spread over the whole epithelial layer Homo sapiens
-
epithelium expression of MMP-7 in the normal oral mucosal epithelium is restricted mainly to the parabasal layers Homo sapiens
-
additional information heparan sulfate proteoglycans, especially perlecan, are extracellular docking molecules for MMP-7 Homo sapiens
-
oral epithelial cell strong expression of MMP-7 in epithelial dysplasia with a two-phase appearance: a clear demarcation of MMP-7-immunopositive (+) lower dysplastic/basaloid cells from non-positive upper keratinized cells Homo sapiens
-
squamous cell carcinoma cell MMP-7 positivity is reduced from carcinoma cells but instead appears in stromal cells Homo sapiens
-

Synonyms

Synonyms Comment Organism
Matrix metalloproteinase 7
-
Homo sapiens
MMP-7
-
Homo sapiens

General Information

General Information Comment Organism
malfunction the enhanced metabolism of perlecan associated with MMP-7 plays an important role in the cell proliferation of oral epithelia in their malignant transformation process Homo sapiens