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Literature summary for 3.4.24.23 extracted from

  • Kaner, R.J.; Santiago, F.; Crystal, R.G.
    Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema (2009), J. Leukoc. Biol., 86, 913-922.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-
extracellular matrix
-
Homo sapiens 31012
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens matrilysins proteolyze a number of extracellular matrix/basement membrane components, including type IV collagens and proteoglycans ?
-
?
Type IV collagen + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMP-7 is activated from a pro-MMP-7 form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelial lining fluid i.e. ELF, proMMP-7 protein is not detectable in any of the 3 HIV1- groups, including HIV1- smokers with early emphysema. In contrast, ELF pro-MMP-7 is readily detectable in the ELF of HIV1+ smokers with early emphysema Homo sapiens
-
lung HIV1- smokers with early emphysema have a trend toward increased relative alveolar matrilysin/MMP-7 gene expression compared with HIV1- healthy smokers and HIV1- healthy nonsmokers. HIV1+ smokers with early emphysema have significantly higher relative expression of alveolar mucosa MMP-7 than both HIV1- healthy smokers and HIV1- healthy nonsmokers. HIV1+ smokers with early emphysema have increased expression over and above the increase in HIV- smokers with early emphysema, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information matrilysins proteolyze a number of extracellular matrix/basement membrane components, including type IV collagens and proteoglycans Homo sapiens ?
-
?
Type IV collagen + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MMP-7
-
Homo sapiens

General Information

General Information Comment Organism
physiological function matrilysin is important for neutrophil migration into the lung in animal models of lung inflammation Homo sapiens