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Literature summary for 3.4.24.23 extracted from

  • Williams, H.; Johnson, J.L.; Jackson, C.L.; White, S.J.; George, S.J.
    MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis (2010), Cardiovasc. Res., 87, 137-146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.23

Activating Compound

Activating Compound Comment Organism Structure
Fas ligand treatment with Fas ligand, Fas-L, increases levels of active MMP-7 by 80% Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Mus musculus
additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
batimastat i.e. BB-94, BB-94 significantly reduces the amount of N-cadherin fragment produced in response to Fas-L Homo sapiens
batimastat
-
 Mus musculus
additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Homo sapiens
additional information MMP-7 knockout or inhibition retards cleavage of N-cadherin and vascular smooth muscle cell apoptosis, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-cadherin + H2O Mus musculus recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?
N-cadherin + H2O Homo sapiens recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?
N-cadherin + H2O Mus musculus C57/BL6J recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57BL/6J mice
-
Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information MMP-7 activity is significantly higher in atherosclerotic plaques than internal mammary arteries Homo sapiens
-
vascular smooth muscle cell
-
 Mus musculus
-
vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MMP-7 assay using DQ-gelatin fluorescent substrate Mus musculus ?
-
 ?
additional information MMP-7 assay using DQ-gelatin fluorescent substrate Homo sapiens ?
-
 ?
additional information MMP-7 assay using DQ-gelatin fluorescent substrate Mus musculus C57/BL6J ?
-
 ?
N-cadherin + H2O
-
 Mus musculus ?
-
 ?
N-cadherin + H2O
-
 Homo sapiens ?
-
 ?
N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Mus musculus ?
-
 ?
N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Homo sapiens ?
-
 ?
N-cadherin + H2O
-
 Mus musculus C57/BL6J ?
-
 ?
N-cadherin + H2O recombinant active MMP-7 increases the amount of N-cadherin fragment by 82% and augments apoptosis by 53% Mus musculus C57/BL6J ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloprotease-7
-
 Mus musculus
matrix metalloprotease-7
-
 Homo sapiens
MMP-7
-
 Mus musculus
MMP-7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens batimastat

General Information

General Information Comment Organism
physiological function MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and atherosclerotic plaque instability Homo sapiens
physiological function MMP-7 mediates cleavage of N-cadherin and promotes vascular smooth muscle cell apoptosis, that can lead to thinning of the fibrous cap and plaque instability Mus musculus