Any feedback?
Literature summary for 3.4.24.23 extracted from
- Matrilysin (matrix metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alphaEbeta7-integrin) (2009), Am. J. Pathol., 175, 2319-2331.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | MMP-7 cleaves E-cadherin from lung epithelium | ? | - |
? |  |
| additional information | Mus musculus C57BL/6 | MMP-7 cleaves E-cadherin from lung epithelium | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice | - |
| Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| dendritic cell | antifibrotic pulmonary dendritic cell | Mus musculus | - |
| epithelium | lung | Mus musculus | - |
| lung | - |
Mus musculus | - |
| additional information | pulmonary CD103+ dendritic cells are significantly increased in bleomycin-injured wild-type compared with Mmp7-/- mice, and CD103+ leukocytes | Mus musculus | - |
| MTC-1 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | MMP-7 cleaves E-cadherin from lung epithelium | Mus musculus | ? | - |
? | |
| additional information | MMP-7 cleaves E-cadherin from lung epithelium | Mus musculus C57BL/6 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase-7 | - |
Mus musculus |
| MMP-7 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | matrilysin regulates pulmonary influx and localization of dendritic cells that express CD103, and E-cadherin cleavage may activate CD103+ dendritic cells to limit inflammation and inhibit fibrosis, overview. Matrilysin effects on CD103-E-cadherin interactions in lung injury, matrilysin expression is increased in lung injury, and it cleaves E-cadherin from injured lung epithelium, overview. Matrilysin regulates pulmonary neutrophil clearance in cronic lung injury, overview | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
