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Literature summary for 3.4.24.23 extracted from

  • Yokoyama, Y.; Gruenebach, F.; Schmidt, S.M.; Heine, A.; Haentschel, M.; Stevanovic, S.; Rammensee, H.G.; Brossart, P.
    Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells (2008), Clin. Cancer Res., 14, 5503-5511.
    View publication on PubMed

Application

Application Comment Organism
medicine induction of specific natural killer cells using monocyte-derived dendritic cells electroporated with MMP-7-mRNA. The induced CTLs elicit an antigen-specific and HLA-restricted cytolytic activity against tumor cells endogenously expressing the MMP-7 protein. MMP-7-specific natural killer cells could be induced using peripheral blood mononuclear cells from a patient with acute lymphoblastic leukemia capable of recognizing the autologous leukemic blasts while sparing nonmalignant cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information induction of specific natural killer cells using monocyte-derived dendritic cells electroporated with MMP-7-mRNA. The induced CTLs elicit an antigen-specific and HLA-restricted cytolytic activity against tumor cells endogenously expressing the MMP-7 protein. MMP-7-specific natural killer cells could be induced using peripheral blood mononuclear cells from a patient with acute lymphoblastic leukemia capable of recognizing the autologous leukemic blasts while sparing nonmalignant cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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