Literature summary for 3.4.24.23 extracted from

Remy, L.; Trespeuch, C.; Bachy, S.; Scoazec, J.Y.; Rousselle, P.
Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 beta3 chain (2006), Cancer Res., 66, 11228-11237.

Search for more literature for 3.4.24.23

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
laminin-5/Laminin-322 + H2O	Homo sapiens	i.e. LN5, composed of alpha3, beta3,and gamma2 chains, is an important component of epithelial basement membranes where it induces firm adhesion and hemidesmosome formation, LN5 and MMP7 are coexpressed in HT29 cells, as well as in HT29 xenograft tumors and human colorectal adenocarcinomas, MMP7-processed LN5 significantly enhances cell motility, overview	90 kDa beta3 chain fragment + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09237	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	MMP7 s generally not expressed by normal differentiated epithelial colon cells, but has been shown to be up-regulated in human colon adenomas and adenocarcinomas	Homo sapiens	-
HT-29 cell	LN5 and MMP7 are coexpressed in HT29 cells, as well as in HT29 xenograft tumors and human colorectal adenocarcinomas, distribution, overview	Homo sapiens	-
additional information	no activity in healthy colon tissue	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	wound-healing activity of cut HT-29 cells, overview	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
laminin-5/Laminin-322 + H2O	i.e. LN5, composed of alpha3, beta3,and gamma2 chains, is an important component of epithelial basement membranes where it induces firm adhesion and hemidesmosome formation, LN5 and MMP7 are coexpressed in HT29 cells, as well as in HT29 xenograft tumors and human colorectal adenocarcinomas, MMP7-processed LN5 significantly enhances cell motility, overview	Homo sapiens	90 kDa beta3 chain fragment + ?	-	?
laminin-5/laminin-332 + H2O	i.e. LN5, specific proteolysis by MMP7 in the beta3 chain at Ala515-Ile516, overview	Homo sapiens	90 kDa beta3 chain fragment + ?	-	?

Synonyms

Synonyms	Comment	Organism
matrilysin 1	-	Homo sapiens
Matrix metalloproteinase 7	-	Homo sapiens
MMP7	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)