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Literature summary for 3.4.24.23 extracted from
- Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway (2005), J. Clin. Pathol., 58, 1242-1248.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is involved in cell dissociation and the subsequent invasion of pancreatic cancer cells. It induces the disruption of tight junction structure and forms a positive feedback loop with activation of the epidermal growth factor receptor mediated MEK-ERK signalling pathway | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreatic cancer cell | exclusive detection of active enzyme in conditioned medium of dissociated cells, detection of proenzyme only in conditioned medium of non-dissociated cells. Enzyme protein is greatly reduced by treatment with the epidermal growth factor receptor inhibitor AG1478 and the mitogen activated protein kinase kinase inhibitor U0126 | Homo sapiens | - |
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Release 2023.1 (January 2023)
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