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Literature summary for 3.4.24.23 extracted from

  • McIntyre, J.O.; Fingleton, B.; Wells, K.S.; Piston, D.W.; Lynch, C.C.; Gautam, S.; Matrisian, L.M.
    Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity (2004), Biochem. J., 377, 617-628.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
analysis use of substrate PB-M7vis as a proteolytic beacon and optical molecular imaging contrast reagent for in vivo detection of enzyme activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
BB-94 [4-(N-hydroxyamino)-(2R)-isobutyl-(3S)-(thienylthiomethyl)-succinyl]-L-Phe-N-methylamine Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 PB-M7vis 25°C, pH 7.4 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
PB-M7vis + H2O fluorogenic substrate based on a polyamino amino dendrimer core of 14.2 kDa covalently coupled with an fluorescein-labeled peptide fluorescein(aminohexanoic acid)RPLALWRS(aminohexanoic acid)Cand with tetramethylrhodamine Mus musculus ?
-
 ?