Literature summary for 3.4.24.23 extracted from

Oneda, H.; Inouye, K.
Effects of dimethyl sulfoxide, temperature, and sodium chloride on the activity of human matrix metalloproteinase 7 (matrilysin) (2000), J. Biochem., 128, 785-791.

Search for more literature for 3.4.24.23

Application

Application	Comment	Organism
medicine	developing and searching for effective inhibitors of matrilysin for cancer diagnosis and therapy	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
dimethyl sulfoxide	competitive inhibition	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.028	-	(7-methoxycoumarin-4-yl)acetyl-L-Pro-Leu-Gly-L-Leu-[N3-2,4-dinitrophenyl-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH2	pH 7.5, 25°C	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Na+	adding of NaCl increases activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(7-methoxycoumarin-4-yl)acetyl-L-Pro-Leu-Gly-L-Leu-[N3-2,4-dinitrophenyl-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH2 + H2O	MOCAc-PLGL(Dpa)AR	Homo sapiens	?	-	?
Azocoll + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
human matrix metalloproteinase 7	-	Homo sapiens
matrilysin	-	Homo sapiens
MMP-7	-	Homo sapiens

Temperature Range [°C]

Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
20	37	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
590	-	dimethyl sulfoxide	pH 7.5, 25°C	Homo sapiens

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Release 2023.1 (January 2023)