Literature summary for 3.4.24.23 extracted from

Sires, U.I.; Griffin, G.L.; Broekelmann, T.J.; Mecham, R.P.; Murphy, G.; Chung, A.E.; Welgus, H.G.; Senior, R.M.
Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites (1993), J. Biol. Chem., 268, 2069-2074.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00089	-	entactin	-	Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mammalia	potentially important role of the enzyme in disruption of basement membranes by tumor or inflammatory cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mammalia	-	enzyme is obtained by transfection of linearized PEE12 PUMP expression vector into NSO mouse myeloma cells	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
entactin + H2O	basement membrane protein which bridges laminin and type IV collagen, enzyme produces multiple but distict cleavages in entactin resulting in peptide fragments ranging from 29000 to 115000 MW, cleavage sites: Glu34-Leu35, Gly275-Leu276, Ala637-Leu638, Cys747-Ile748	Mammalia	peptide fragment ranging from 29000 to 115000 MW	-	?
additional information	potentially important role of the enzyme in disruption of basement membranes by tumor or inflammatory cells	Mammalia	?	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mammalia

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Release 2023.1 (January 2023)